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Publications

Biological Pathways 

  • Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response. Intern. J. Mol Sci. 21, 6088; doi:10.3390. Ruis et al., (2020)
  • The integrated stress response: From mechanism to disease. Science Review 368, 6489: Costa-Mattioli M & Walter P (2020).
  • Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529, 326-335. Wang M. & Kaufman R.J.,(2016). 
  • The unfolded protein response in neurodegenerative disorders – therapeutic modulation of the PERK pathway. FEBS J. doi: 10.1111/febs.14422. Hughes D. & Mallucci G.R., (2018). 
  • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348, 239-242. Das I. et al, (2015). 
  • Pharmaceutical integrated stress response enhancement protects oligodendrocytes and provides a potential multiple sclerosis therapeutic. Nature Commun. DOI: 10.1038/ncomms7532. 2015: Way SW. et al, (2015).

ALS

CMT 

  • Treatment with IFB-088 improves neuropathy in CMT1A and CMT1B mice. Mol Neurobiol. 59(7), 4159-4178. Bai Y. et al, (2022).
  • Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348, 239-242. Das I. et al, (2015). 
  • Charcot-Marie-Tooth disease: an overview of genotypes, phenotypes, and clinical management strategies. PM&R 6, 342-355. El-Abassi R. et al, (2014). 
  • Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice. J. Exp. Med. 210(4), 821-838. D’Antonio M. et al, (2013).

MS 

Science Magazine