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Integrated Stress Response

InFlectis drugs amplify the Integrated Stress Response (ISR) by selectively inhibiting the dephosphorylation of eIF2α.

  • Healthy protein balance is essential to keeping cells functioning and alive. The ISR serves as a central command center to maintain protein levels or to repair misshapen proteins. In this way, the ISR naturally protects cells against stress caused, for example, by mitochondrial calcium overload triggered by glutamate-mediated excitotoxicity, oxidative stress and genetics.
  • In healthy functioning cells, the ISR corrects stress-related imbalances on a regular basis. However, excessive or prolonged stress can prove toxic and overwhelm the ISR, create an irreversible protein imbalance and cause cell death. When this occurs in cells of the central or peripheral nervous system, it can result in progressive neuromuscular and neuroinflammatory diseases.
  • Exploiting the ISR’s natural defense offers tremendous potential for the development of a new class of therapies. Led by InFlectis, this area of research is rapidly advancing, resulting in new treatments under development for a variety of disease affecting the central nervous system (CNS) and peripheral nervous system (PNS).
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